Scientists from the University of Arizona recently disclosed the results of their latest study. They found that metformin, a drug generally employed in the type 2 diabetes treatment, can also be used for treating heart failure with preserved ejection fraction (HFpEF). This is a health condition estimated to affect more than 8% of individuals of age group 65+ by 2020. The research is available online in the Journal of General Physiology. It demonstrates that metformin relaxes an important heart muscle protein named titin, letting the heart to appropriately fill with blood before pumping it around all body parts.
Almost 50% of individuals suffering from heart failure are believed to have HFpEF. In this condition, the heart has the capability to contract properly. However, as the wall of the left ventricle is stiffer than regular, it is not able to completely relax between beats, minimizing heart’s capability to fill with blood. This decreases the blood supply to the rest of the body.
On a similar note, researchers from the Wake Forest School of Medicine recently disclosed the results of their latest study. According to the study, bacteria that structure the gut microbiome might be the issue of concern. In a study of over 100 presently published researches in rodents and humans, the team at the School of Medicine studied how gut bacteria either inhibited or enhanced a drug’s efficiency. The latest study can be accessed online in the journal EBioMedicine.
Hariom Yadav, Ph.D., Assistant Professor, Molecular Medicine, School of Medicine, explained that some drugs work well when administered intravenously. They go straightly into the blood circulation. However, when they are given orally and pass through the gut, they are not effective. On the other hand, metformin, a frequently used anti-diabetes drug, is found to be working well when taken orally and does not show effectiveness when given through an IV.
Working as an Editor and Content Writer for over 3 Years, Melissa has skilled herself to write articles and reports regarding the day-to-day events, breakthrough, inventions, and launch news about the Science field. When not writing, she likes to read books of the fictional, suspense, and inspirational genre. She also loves to explore new places to spend time with friends and family whenever possible or, being a food-lover, try exploring new food places.